**Strong critical reception and a franchise-record $60 million domestic opening for Zach Cregger’s Resident Evil reboot have driven early momentum, yet trader consensus overwhelmingly favors a sub-$26 million second weekend (99.5% implied probability).** The R-rated horror film earned a 96% Rotten Tomatoes score and B+ CinemaScore, the best in the series, helping it surpass tracking and prior entries like Resident Evil: Afterlife. Typical genre drops of 50% or more from such openings, combined with modest midweek holds visible in the $87 million domestic total by September 25, support the steep decline expectation. Limited international expansion and September competition further cap upside. An upset above $26–29 million would require exceptional word-of-mouth legs or unusually front-loaded holdover business rarely seen in horror titles.