**Tank Bigsby holds the highest implied probability at 49% to lead Week 2 in rushing yards, driven primarily by Saquon Barkley's stinger injury that sidelined him for much of the first half of Philadelphia's game against the Titans.** Bigsby, acquired by the Eagles in 2025 and established as the clear RB2 behind Barkley, stands to absorb a significantly larger share of carries and snaps if the starter's availability remains limited. Other contenders such as Kenneth Walker III, Derrick Henry, Bijan Robinson, and Jahmyr Gibbs enter with 12.5–25% odds based on Week 1 workloads and favorable or neutral matchups, though most operate in established committees or against stout defenses. Recent injury reports, including Rico Dowdle's toe issue and various questionable designations, add volatility, but the Eagles' backfield shift represents the clearest near-term catalyst shifting trader consensus toward Bigsby for this single-game outcome.